Correction: DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

摘要

We showed in our study [1] that SNP rs10876043 in thedisco-interacting protein 2 homolog B gene (DIP2B) wasassociated with the first principal component of methyla-tion. Although the analyses and result remain unchanged,it appears that this observation is likely due to a genotyp-ing artifact. That is, the reported rs10876043 genotypesdiffer according to Hap Map Phase (cell lines genotyped inPhase 1/2 have reported genotypes AG and GG, whilePhase 3 cell lines have genotype AA). The 1000 Genomesdata suggest the correct genotype is probably AA for all ofthese YRI individuals. These genotype differences betweendifferent phases of the Hap Map Project, coupled with asmall difference in mean methylation between Phase 1/2vs 3 cell lines appear to have produced an artifactual asso-ciation. Other analyses in the paper controlled for the topprincipal components and should therefore be robust tothis type of effect.