Control of pre-mRNA processing by extracellularsignals: emerging molecular mechanisms

摘要

Alternative splicing is an important mechanism to regulate gene expression. At least 30% of all human genes are alternatively spliced. This process can be regulated by extracellular signals that include stress and cellular activity. Splice site selection is regulated by a multiprotein complex Its composition can be regulated by either releasing proteins from nuclear storage sites or by changingprotein:protein, as well as protein:RNA Interactions by serine and tyrosine phosphorylation.