Context-Dependent Role of IKK???2 in Cancer

摘要

Inhibitor of nuclear factor kappa-B kinase subunit beta (IKK???2) is a kinase principally known as a positive regulator of the ubiquitous transcription factor family Nuclear Factor-kappa B (NF-???oB). In addition, IKK???2 also phosphorylates a number of other proteins that regulate many cellular processes, from cell cycle to metabolism and differentiation. As a consequence, IKK???2 affects cell physiology in a variety of ways and may promote or hamper tumoral transformation depending on hitherto unknown circumstances. In this article, we give an overview of the NF-???oB-dependent and -independent functions of IKK???2. We also summarize the current knowledge about the relationship of IKK???2 with cellular transformation and cancer, obtained mainly through the study of animal models with cell type-specific modifications in IKK???2 expression or activity. Finally, we describe the most relevant data about IKK???2 implication in cancer obtained from the analysis of the human tumoral samples gathered in The Cancer Genome Atlas (TCGA) and the Catalogue of Somatic Mutations in Cancer (COSMIC).