The ILAE study featured is likely to be as definitive as we will see for some time, until the next several thousand patients with epilepsy are sequenced and compared to the ever-growing available repositories of non-epilepsy controls available for analysis. While findings in GWAS do not translate immediately to the bedside in that predicting risk for an individual carrying an at-risk allele is not as simple as it is for dominant and recessive genotypes, scientifically, the ILAE GWAS meta-analysis represents a move toward a deeper understanding of the highly prevalent yet genetically elusive complex epilepsies.
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