Neuropathology of the Blood-Brain Barrier in Epilepsy: Support to the Transport Hypothesis of Pharmacoresistance

摘要

Finally, since depth electrode insertion was not associated with overexpression of P-glycoprotein, this type of injury did not help characterize the temporal pattern of P-glycoprotein overexpression. That said, the findings did alert clinicians that depth electrode implantation may not be a benign process since it results in chronic inflammatory changes and disruption of the blood-brain barrier. Although experience suggests that these pathologic changes are often clinically inconsequential, more studies should reassess long-term complications of depth electrode monitoring.