Neuropathology of the blood-brain barrier in epilepsy: support to the transport hypothesis of pharmacoresistance.

摘要

Approximately one-third of individuals with epilepsy will continue to have seizures despite treatment with antiepilep-tic drugs (AEDs), and failure of one AED to achieve seizure control often predicts failure of subsequent AED regimens (1). Understanding the mechanisms of drug-resistance in epilepsy is of extreme importance because of potential therapeutic implications. A number of hypotheses exist regarding these mechanisms. The intrinsic severity hypothesis argues that since drug resistance is independent of the choice of AED, then it must be related to neurobiological factors that increase disease severity (2).