Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6

Maria Luisa Feo; Michael S. Gross; Barbara P. McGarrigle; Ethel Eljarrat; Damià Barceló; Diana S. Aga; James R. Olson

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Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6

机译：BDE-47潜在毒性代谢物的生物转化主要由人类CYP2B6介导。

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Background: Previous studies have indicated that cytochrome P450s (CYPs) are involved in the metabolism of polybrominated diphenyl ether (PBDE) flame retardants in humans, resulting in the formation of hydroxylated PBDEs (OH-PBDEs) that are potentially mo

机译：背景：先前的研究表明，细胞色素P450（CYP）参与了人类多溴二苯醚（PBDE）阻燃剂的代谢，导致形成羟基化的PBDEs（OH-PBDEs）。

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《Environmental health perspectives.》 |2013年第4期|共7页
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Maria Luisa Feo; Michael S. Gross; Barbara P. McGarrigle; Ethel Eljarrat; Damià Barceló; Diana S. Aga; James R. Olson;
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中图分类环境卫生、环境医学;
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1. Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6 [J] . Luisa Feo Maria, Gross Michael S., McGarrigle Barbara P., Environmental health perspectives. . 2013,第4a6期

机译：BDE-47潜在毒性代谢物的生物转化主要由人类CYP2B6介导。
2. Cytochrome P450-Mediated Biotransformation of Sorafenib and Its N-Oxide Metabolite: Implications for Cell Viability and Human Toxicity [J] . Gillani Tina B., Rawling Tristan, Murray Michael Chemical research in toxicology . 2015,第1期

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3. Biotransformation of brominated flame retardants into potentially endocrine-disrupting metabolites, with special attention to 2,2',4,4'-tetrabromodiphenyl ether (BDE-47) [J] . Hamers Timo, Kamstra Jorke H., Sonneveld Edwin, Molecular Nutrition and Food Research . 2008,第2期

机译：将溴化阻燃剂生物转化为可能破坏内分泌的代谢物，特别注意2,2'，4,4'-四溴二苯醚（BDE-47）
4. Identification of Rilpivirine Metabolites in Human Liver Microsomes and Characterization of Cytochrome P450 Enzymes Involved in the Biotransformation by LC-MS/MS [C] . Josiane de Oliveira Cardoso, Jessica Bo Li Lu, Regina Vincenzi Oliveira, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：LC-MS / MS中，LC-MS / MS中患者肝脏微粒体中瑞培代谢产物的鉴定及涉及生物转化的细胞色素P450酶的表征
5. Polychlorinated biphenyl (PCB)-induced oxidative stress mediates cytotoxicity in human breast and prostate epithelial cells [D] . Zhu, Yueming 2011

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6. Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6 [O] . Maria Luisa Feo, Michael S. Gross, Barbara P. McGarrigle, 2013

机译：BDE-47潜在毒性代谢物的生物转化主要由人类CYP2B6介导。
7. Inhibition of the Human ABC Efflux Transporters P-gp and BCRP by the BDE-47 Hydroxylated Metabolite 6-OH-BDE-47: Considerations for Human Exposure [O] . Satori A. Marchitti, Christopher S. Mazur, Caleb M. Dillingham, 2016

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8. Biosynthesis and Biotransformation of Glutathione S-Conjugates to Toxic Metabolites. (Reannouncement with New Availability Information). [R] . Anders, M. W., Dekant, W., Elfarra, A. A., 1988

机译：谷胱甘肽s-共轭物与有毒代谢物的生物合成和生物转化。（重新公布新的可用性信息）。

Biotransformation of BDE-47 to Potentially Toxic Metabolites Is Predominantly Mediated by Human CYP2B6

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