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首页> 外文期刊>Endocrinology, Diabetes & Metabolism Case Reports >Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma
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Euglycemic diabetic ketoacidosis: a diagnostic and therapeutic dilemma

机译:正常血糖糖尿病酮症酸中毒:诊断和治疗的困境

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SummaryEuglycemic diabetic ketoacidosis (EDKA) is a clinical triad comprising increased anion gap metabolic acidosis, ketonemia or ketonuria and normal blood glucose levels 200?mg/dL. This condition is a diagnostic challenge as euglycemia masquerades the underlying diabetic ketoacidosis. Thus, a high clinical suspicion is warranted, and other diagnosis ruled out. Here, we present two patients on regular insulin treatment who were admitted with a diagnosis of EDKA. The first patient had insulin pump failure and the second patient had urinary tract infection and nausea, thereby resulting in starvation. Both of them were aggressively treated with intravenous fluids and insulin drip as per the protocol for the blood glucose levels till the anion gap normalized, and the metabolic acidosis reversed. This case series summarizes, in brief, the etiology, pathophysiology and treatment of EDKA.Learning points:Euglycemic diabetic ketoacidosis is rare.Consider ketosis in patients with DKA even if their serum glucose levels are normal.High clinical suspicion is required to diagnose EDKA as normal blood sugar levels masquerade the underlying DKA and cause a diagnostic and therapeutic dilemma.Blood pH and blood or urine ketones should be checked in ill patients with diabetes regardless of blood glucose levels.
机译:总结血糖性糖尿病酮症酸中毒(EDKA)是一种临床三联征,包括阴离子间隙代谢性酸中毒,酮症或酮尿症增加以及正常血糖水平低于200?mg / dL。由于正常血糖会掩盖潜在的糖尿病性酮症酸中毒,因此这种情况是一种诊断挑战。因此,需要高度的临床怀疑,并排除其他诊断。在这里,我们介绍了两名接受常规胰岛素治疗的患者,他们被诊断出患有EDKA。第一例患者出现胰岛素泵功能衰竭,第二例患者出现尿路感染和恶心,从而导致饥饿。按照协议中的规定,他们都积极地用静脉输液和胰岛素滴注治疗血糖水平,直到阴离子间隙恢复正常,并且代谢性酸中毒逆转。该病例系列简要概述了EDKA的病因,病理生理学和治疗方法。学习要点:血糖性糖尿病酮症酸中毒很少见,即使DKA患者的血糖水平正常也应考虑酮症,需要高度临床怀疑以诊断EDKA为正常的血糖水平会掩盖潜在的DKA并引起诊断和治疗难题。无论血糖水平如何,糖尿病患者应检查血液的pH值和血液或尿酮。

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