新诊断2型糖尿病患者胰岛素抵抗指数、空腹甘油三酯及葡萄糖简易指数、空腹血糖/空腹胰岛素与正常血糖高胰岛素钳夹试验的一致性分析

摘要

目的 分析新诊断T2DM患者稳态模型胰岛素抵抗指数(HOMA-IR)、空腹 TG及葡萄糖简易指数(TyG)、FPG/FIns与正常血糖高胰岛素钳夹试验的一致性. 方法 选取新诊断 T2DM 患者137例,基线水平时测定FPG、FIns,TG,外周葡萄糖清除率(GDR)并对 HOMA-IR、TyG指数、FPG/FIns与GDR的一致性进行评估. 结果 HOMA-IR及FPG/FIns、TyG指数与GDR的差值及一致性范围分别为-3.776(-7.495~ -0.055)、-8.428(-25.311~8.456)、1.075(-2.598~4.749);三者的组内相关系数分别为0.797、0.503、0.236. 结论 HOMA-IR、TyG指数、FPG/FIns与GDR的一致性在可接受范围内,但FPG/FIns及TyG可靠性差[组内相关系数(ICC)＜0.6],不能广泛应用.%Objective To assess the agreement between homeostasis model assessment for insulin resistance index(HOMA-IR),a simple index of fasting serum triglyceride(TG)and plasma glucose(TyG index)and fasting plasma glucose(FPG)/fasting insulin(FIns)with glucose disposal rate(GDR)in patients with newly diagnosed type 2 diabetes(T2DM). Methods A total of 137 patients with newly diagnosed T2DM were enrolled.The levels of FPG,FIns,TG and GDR were measured in baseline. Agreement analysis was performed to assess their agreements. Results The bias and limit of agreement of HOMA-IR,FPG/FIns and TyG index with GDR were - 3.776(- 7.495 ~ - 0.055),- 8.428 (-25.311~ 8.456)and 1.075(- 2.598 ~ 4.749),respectively,and their intra-class correlation coefficients(ICC)were 0.797,0.503 and 0.236,respectively. Conclusion HOMA-IR,TyG index and FPG/FIns showed the acceptable agreement with the GDR. The poor reliability of FPG/FIns and TyG index(ICC＜0.6)limits its clinical application.