A COMPARATIVE STUDY OF EFFICACY OF AZITHROMYCIN AND CHLOROQUIN FOR THE TREATMENT OF UNCOMPLICATED PLASMODIUM FALCIPARUM MALARIA

摘要

Objective:.To.compare.the.efficacy.of.Azithromycin.relative.to.chloroquin.as.treatment.of.plasmodium.falciparum.malaria..Methods.and.Materials.:.In.this.study.33.cases.of.uncomplicated.falciparum.malaria.between.15‐75.years.of.age.were.studied,.irrespective.of.race.and.sex..Patients.were.hospitalized.for.7.days.and.weekly.follow.up.was.done.for.28.days..Patients.were.randomly.divided.into.two.groups..Group.A.(16.patients).was.given.Tab..chloroquine.1500.mg.orally.for.3.days..Group.B.(17.patients).was.given.Tab.Azithromycin.1000.mg.orally.for.3.days..Scoring. of. the. clinical. symptoms. was. done. every. day. during. hospital. stay. and. on. follow‐up. weekly. for. 28. days.. Peripheral. smear.for.Malaria.Parasite.was.made.every.day.till.7.days.and.there.after.on.14th,.21s t.and.28th.day..Observation:. There. were. rapid. deffervescence. of. fever. after.azi thromycin. therapy. on. day. 1. &. day. 2..Same. results. were. observed. in.chloroquin.group...Conclusions:. From. the. present.study. it. can. be. concluded. that,. the. Azithromycin. is. a. safe.and.effective. drug. for.the.treatment. of.uncomplicate d.plasmodium.falciparum.malaria,.because.of.its.quick.clearance.of.symptoms.and.no.serious.adverse.effects..