EFFECT OF TAMSULOSIN A SELECTIVE α1-ANTAGONIST ON GLUCOSE HOMEOSTASIS IN RATS

摘要

Objective : To assess the effect of tamsulosin (α 1 -antagonist) on blood sugar and adrenaline levels in rats. Methods : Wistar rats were divided in to four groups (n=6), Group-I (Normal control) administered normal saline, Group-II, Group-III &Group-IV induced diabetes by administering Streptozotocin IV 50 mg/kg. Group III and Group-IV were administered Tamsulosin 1mg/kg and Glimepiride 10μg/kg respectively for twenty one days. Serum insulin, adrenaline and blood glucose were estimated at before and after drug treatment. Results : Adrenaline and insulin levels were increased significantly (p<0.005) in Diabetic control and Tamsulosin treated diabetic rats compared to Normal control rats. Blood glucose levelsincreased significantly (p<0.005) in Tamsulosin treated diabetic rats compared to Diabetic control rats. All the three parameters are compared at the end of drug treatment. Conclusion: Several studies interpreted a potential role of the α-receptor in glucose metabolism. Inhibition of the α1-receptor pathway can lead to a decreased glucose uptake, and hence an increased plasma glucose concentration. Several studies in one or the other way indicating the correlation between diabetes and BPH and probably in such condition tamsulosin a α1 antagonist is the drug of choice along with oral hypoglycemic agents. Literature survey also shows that there is increase in the blood glucose levels during the use of tamsulosin which impacts blood sugar levels especially in diabetic state. T.h.is study shows increase in blood glucose levels with the use of tamsulosin is making further complications in diabetic patients. This adverse drug reaction and the proposed mechanism need to be proven further. Keywords: α 1 -antagonist, Wistar rats, Streptozotocin.