FORMULATION OF RAPID MOUTH DISSOLVING TABLETS OF CETIRIZINE di HCL USING SUBLIMATION METHOD

摘要

Patient.compliance.is.a.prerequisite.for.the.success.of.any.drug.delivery.system.which.culminated.into.the.design.of.mouth.dissolving.drug.delivery.system.beside.older.NDDS..Cetirizine.dihydrochloride.is.a.non‐sedative.antihistamine.with.potent.antiallergic.action..The.purpose.of.this.study.was.to.formulate.mouth‐dissolving.tablet.that.have.quick.onset.of.action,.not.require.water.for.swallowing.of.tablet,.less.disintegration.and.dissolution.time,.hence.providing.faster.relief.to.the.patient..In.order.to.eliminate.the.rough.texture.in.mouth,.we.attempted.to.prepare.high.porosity.rapidly.mouth‐dissolving.tablets.by.using.water.soluble.material.(Manni tol).along.with.a.subliming.material.(Camphor).and.to.select.the.best.formulation.based. on. in. vitro.and.in. vivo.study..In.this.study,.Cetirizine.diHCl.E.P,.D‐Mannitol,.DL‐Camphor. was.used. in.various.ratios.. The. drug.(5%). with.excipients.was.mixed.in.modified.rotary.flask.shaker.at.30.rpm.(inclined.at.an.angle.of.500).for.30.minutes.and.compressed.into.tablet.followed.by.sublimation.using.vacuum.oven.at.600mm.Hg.at.800C.for.1.hour..Tablets.prepared.with.drug,.mannitol.and.camphor.in. ratio.1:16:3.showed.least.disintegration.time.(less.than.1min..without.shaking),.maximum.in.vitro.dissolution.rate.(T50 %=4.75.min.,.T9 0%.=.13.75min.).and.least.in.vivo.mouth.disintegration.time.(17.58.sec)..