Nanocomposites of Poly (4-Vinyl Pyridine-co-Styrene)/ Hydroxyapatite: Synthesis, Characterization and Its Biomedical Application

摘要

Currently composite materials have gained momentum in the field of orthopedics and maxillofacial surgery. Among the composite materials, ceramic/polymer possesses significant advantages of high mechanical reliability and excellent biocompatibility for applications in load bearing areas. In this work, PVPCS(Poly (4-vinyl pyridine –costyrene))/HAp nanocomposites of varying weight percentages were synthesized and characterized physical-chemically by XRD, FTIR, ~(31)P NMR, TGA, DTA and FE-SEM and biologically by antimicrobial and anti-inflammatory assays for evaluate their potential use for biomedical applications. The results indicated that the size and crystallinity of HAp nano particles decreases with increase in PVPCS concentration in the composite. SEM confirmed the presence of HAp nano rod crystals in PVPCS matrix. The nano PVPCS20/HAp demonstrated the highest antifungal and antibacterial activity and favorable inhibition of human cell hemolysis. The designed PVPCS/HAp nanocomposites constitute promising candidates for biomedical applications.