Hepatocellular carcinoma is the fourth common cancer globally occurring by many factors such as mycotoxins, chemicals, genetical, viral factors etc. AFB1 is a potent mycotoxin classified in group I carcinogens by IARC found in contaminated food stuffs. The present study was aimed at evaluating the ethanolic extract of whole plant of sida cordifolia L against AFB1 induced HCC. Hepatocellular carcinoma (hepatoma) was induced in wistar rats by intra peritoneal administration of AFB1 (250μg/kg/dose) for 7 days. The effect of concurrent administration of ethanolic extract of sida cordifolia L. at doses of 250mg/kg and 500mg/kg were given orally was observed by estimating the serum levels of SGOT, SGPT, ALP, LDH, GGT and TP. DNA, RNA and TP were estimated from liver. Antioxidant and pro-oxidant studies were also measured. The results showed a significant decrease in serum SGOT, SGPT, ALP, LDH and GGT and increase in total proteins of groups treated with EESC. Elevated DNA and RNA found decreased with a prominent increase in total proteins in liver of EESC groups. Significant increase in antioxidants and a decrease in lipid peroxidation were also observed. The extracts at both doses (250mg/kg and 500 mg/kg b.w) shows a significant (p<0.001) reversal of altered biochemical, molecular and antioxidant parameters showing that sida cordifolia L. possess antioxidant and antitumor activity.
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机译：肝细胞癌是真菌毒素，化学物质，遗传，病毒等多种因素引起的全球第四大常见癌症。AFB1是一种有力的霉菌毒素，被IARC分类为I类致癌物，被污染的食品中发现。本研究的目的是评估针对AFB1诱导的HCC的茄科植物全株乙醇提取物。通过腹膜内给予AFB1（250μg/ kg /剂量）7天，在wistar大鼠中诱发肝细胞癌（hepatoma）。通过估计血清SGOT，SGPT，ALP，LDH，GGT和TP的水平，观察到口服250mg / kg和500mg / kg的茄科植物乙醇提取物同时给药的效果。 DNA，RNA和TP均来自肝脏。还测量了抗氧化剂和促氧化剂研究。结果显示，血清SGOT，SGPT，ALP，LDH和GGT显着降低，而用EESC治疗的组的总蛋白质增加。发现EESC组肝脏中的DNA和RNA升高，总蛋白显着增加。还观察到抗氧化剂的显着增加和脂质过氧化的减少。两种剂量（250mg / kg和500mg / kg b.w）的提取物均显示出生化，分子和抗氧化剂参数发生显着（p <0.001）逆转，表明sida cordifolia L.具有抗氧化剂和抗肿瘤活性。
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