Design and in-vitro Evaluation of Floating Microspheres Containing Lactulose Using Emulsion Solvent Evaporation Technique

摘要

The present investigation was concerned with formulation and evaluation of floating microspheres for Lactulose using Ethyl cellulose & HPMC as a release retarded material were prepared using emulsion solvent evaporation technique. Eleven different batches of microspheres were prepared by varying the concentration of drug polymer ratio from 1:0.5 to 1:5. The microspheres were characterized for drug content, percentage yield, particle size analysis and surface morphology. The results of all the physiochemical tests of all formulations were found to be favorable. In-vitro floatability studies reveled that most of the microspheres (64 - 94%) were floatable. The in-vitro % drug release was found to be in range of 89.18 to 97.89 %. At the end of 14 hrs. Formulation F showed best appropriate balance between buoyancy and drug release rate. Optimized formulation F was evaluated for FTIR, DSC and SEM. DSC and FTIR studies showed that the nature of pure drug Lactulose remains unaffected till the completion of process of microspheres formation. SEM photographs showed that the Floating microspheres were spherical in nature with smooth surface and uniform distribution of the drug within the microsphere.