Development and Validation of a Spectrophotometric Method for Determination of Aliskiren in Tablets Using O-Phthalaldehyde”

摘要

The objective of this study was to evaluate the combination of solid dispersion and melt adsorption technologies for enhancing the dissolution rate of Felodipine. Polyethylene glycol (PEG) 6000 was used as hydrophilic carriers in 1:1, 1:3 and 1:5 weight ratios (FEL: PEG 6000) for the preparation of solid dispersions, and mannitol was utilized as an adsorbent for the preparation of solid dispersion adsorbates. The solid dispersion adsorbates were evaluated by differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and in vitro drug release study. The dissolution rates of FEL solid dispersion adsorbates were observe much faster when compared to solid dispersions alone and physical mixture. The results were supported by the DSC, FTIR, SEM.