DEVELOPMENT AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SALBUTAMOL SULPHATE BY SUPERDISINTEGRATING AGENTS

摘要

The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using superdisintegrating agents. Recently fast disintegrating drug delivery system have started gaining popularity and acceptance as new drug delivery system, because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as a bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Ac-di-sol, Polyplasdone and Primojel were used as super disintegrating agents, while microcrystalline cellulose and mannitol were used as diluents. Direct compression technique was used as it requires conventional tablet machinery and thus economical process. Formulations containing Ac-di-sol as super disintegrating agent show rapid in-vitro and in-vivo dispersion time as compared to other formulations.