Different Doses of Sublingual Misoprostol versus Methylergometrine for the Prevention of

摘要

Objective: In the poor underdeveloped countries, anaemia is very common in pregnant women. Maternal mortality is four timeshigher in severely anaemic women than non-anaemic ones and postpartum haemorrhage (PPH) is the most common cause ofdeath. Its main cause is uterine atony, which accounts for more than 70%. The objective of this study is to evaluate the use ofsublingual misoprostol in different doses of 600, 800 and1000μg in management of the third stage of labor, with regards toblood loss and incidence of atonic postpartum haemorrhag (APPH).Study Design: Double blind randomized controlled studyMethods : One thousand and two hundred parturient were studied in a control and three study groups, each composed of 300women. Methylergometrine 0.2 mg IM injection and sublingual misoprostol 600, 800 and 1000 μg tablets were given to womenin control and the three study groups respectively, immediately after delivery.Outcome Measures:Duration of the third stage of labour, Blood loss in the third stage of labour, Outcomes in anaemic compared to non-anaemicwomen , Incidance of atonic postpartum haemorrhage in different groups,Haemoglobin deficit after 24 hrs of delivery, Changes in the women’s blood pressure during the study,Side effects of the drug, and, Women’s acceptability of sublingual misoprostol administration.Results : Only significant reduction in blood loss and haemoglobin deficits were seen in the third stage of labour and afterdelivery in women used misoprostol doses of 800 μg and 1000 μg. The incidences of PPH in studied women and controls werealmost similar, ranging between 2 and 3%. Similar results were seen in anaemic and non-anaemic women with a higherincidence of APPH in the non-misoprostol user anaemic women. Side effects of the drug were dose related.Conclusion : Misoprostol in high dose may be used for managing third stage of labour to reduce maternal morbidity andmortality due to APPH particularly, in the poor underdeveloped countries where, facilities to deliver in health centers, purchaseand store the oxytocic ampoules or medically trained persons are not readily available in all places. Benefits of large dosemisoprostol outweigh its side effects.PDFHow to Cite Soltan, M., El-Gendi, E., Imam, H., & Fathi, O. (1). Different Doses of Sublingual Misoprostol versus Methylergometrine for the Prevention of. International Journal of Health Sciences, 1(2). Retrieved from https://ijhs.org.sa/index.php/journal/article/view/93More Citation FormatsACMACSAPAABNTChicagoHarvardIEEEMLATurabianVancouverDownload CitationEndnote/Zotero/Mendeley (RIS)BibTeXIssueVol 1 No 2 (1): Issue 2SectionOriginal Paper Authors who publish with this journal agree to the following terms:Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).Make a SubmissionInformationFor ReadersFor AuthorsFor LibrariansIndexed in PubMed, PubMed Central, EBSCO Host, Emerging Sources Citation Index (Thomoson Reuters), DOAJ, Google Scholar, Microsoft Academic