Composition analysis of A, C, G, T nucleotides in genes responsible for the Long QT Syndrome

摘要

Long QT syndrome (LQTS) is a congenital disorder characterized by a prolongation of the QT interval on ECG and a propensity to ventricular tachyarrhythmia, which may lead to syncope, cardiac arrest, or sudden death. LQTS is caused by mutations of the genes for cardiac potassium and sodium or calcium ion channels. 8 genes have been identified.LQT1 (KCNQ1), LQT2 (KCNH2), and LQT3 (SCN5A) account for most cases of LQTS, with estimated prevalence of 45%, 45%, and 7%, respectively. We have used the analogy of genome analysis and VIRUS (vital information recourse under siege) and analyzed Since KCNQ1, KCNH2 and SCN5A genes are playing an important role in LQTS disease, we have taken their nucleotide sequences in FASTA format and submitted them in Geneboy(www.dnai.org).And studied their composition of nucleic acids (A,C,T,G),and we have received results for genes KCNQ1,KCNH2 such that their nucleic acid composition approximately same, being their prevalence percentage is same.