Secretory breast carcinoma: a report of two cases misdiagnosed on frozen section

摘要

Secretory breast carcinoma (SBC) is an extremely rare but distinctive subtype of malignant breast tumor. Herein, we represent two cases of SBC. The morphologic characters of the two cases showed three distinctive histological characters: granular eosinophilic cytoplasm, intracellular/extracellular secretions and prominent fibrous septa among tumor nest. They were misdiagnosed as benign hyperplasia or neoplasm by intraoperative frozen section analysis. Appearance of coagulative necrosis in frozen section could contribute to the diagnosis for malignant tumor. Careful radiological and histopathological examination is also required to arrive at an accurate diagnosis. Total tumor removal can usually be achieved with an appropriate surgical technique.