Clinicopathologic profile of extranodal folliculardendritic cell sarcoma in the mesentery of smallintestine: a study of two cases with literature review

摘要

Aim: To analyze the clinicopathologic profile of the extranodal follicular dendritic cell sarcoma (FDCS) inthe mesentery of small intestine. Materials and methods: The clinical observations and histopathologic andimmunohistochemicalfeatures of FDCS were analyzed in the mesentery of small intestine. Results: FDCS had no characteristicclinical manifestations. Histology showed oval sarcoma cells forming fascicles of spindle cells and whorls.Sarcoma tissue was distributed pervasively and often mixed with some T lymphoid cells. Immunohistochemicalmarkers showed the follicular dendritic sarcoma cells were positive for CD21, CD23, CD35, D2-40 and vimentin,and weakly positive for CD68, and S-100, while EMA, CD1a, desmin, AE1/AE3, CD45RO, CD3, LCA and MPO werenegative. Conclusion: FDCS is a rare malignant tumor in the mesentery of small intestine.I Its diagnosis dependson the histopathology and immunohistochemical staining, and its prognosis is uncertain. Surgical operation is thefirst choice of treatment.