ANTIBIOTIC SENSITIVITY PATTERN IN NEONATAL INTENSIVE CARE UNIT OF A TERTIARY CARE HOSPITAL OF INDIA

摘要

Objective:To do audit of the antimicrobial (AM) sensitivity pattern in Neonatal Intensive Care Unit (NICU). Methodology:This retrospective case series based on a case record form analysis of a tertiary care hospital of NICU was carried out for the duration Jan-2010 to Mar-2011. Data of demographics, diagnosis, type of infection, indication of the use of the AMs, hospital stay, specimen, causative agent, sensitivity pattern, prescribed antibiotics were collected in a case record form. Antibio tic sensitivity testing was performed through CLSI method. Result:Out of 676 admitted neonates, 52 neonates showed bacteriological proven infection in 58 cultures. Septicemia – 88.46% (56.52% early onset and 43.48% late onset) was the predominant cause of infection. S. epidermidis (37.93%) was the most commonly isolated organism followed by K. pneumoniae (22.41%). 78.78% and 44% of isolated strain of gram positive and gram negative have shown multiple resistance (p=0.012). Gentamicin (100%), vancomycin (96.87%), and ciprofloxacin (90.9%) were most sensitive drugs for GPIs. 68.19% and 55.56% of isolated strains of S. epidermidis and S. aureus were resistant to cloxacillin. Levofloxacin (100%), imipenem (100%), meropenem (100%), ofloxacin (88%) and gentamicin (85.71%) were most effective drugs for GNIs. Sensitivity of third generation cephalosporins for GNIs were: cefotaxime (57.14%), ceftriaxone (57.14%), cefoperazone (50%) and ceftazidime (50%). The most commonly used AMs were cefotaxime (59.09%), amikacin (55.45%), levofloxacin (54.55%) and piperacillin + tazobactam (51.82). Conclusion:Cloxacillin resistant gram positive organisms and third generation cephalosporins resistant gram negative bacilli were the predominant antimicrobial resistant organisms