HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACTS OF CHRYSANTHEMUM INDICUM FLOWERS ON PARACETAMOL INDUCED LIVER INJURY IN ALBINO RATS

摘要

Objective: The present investigation was evaluated that protective activity of aqueous extract of flowers of Chrysanthemum indicum studied against paracetamol-induced hepatotoxicity in animal model. Methods: Bioactive functional groups, such as alcohol, carboxylic acid, and amines, were present in the aqueous extract of flowers of C. indicum identified by Fourier transform infrared spectroscopy. The animals were grouped into 5 and each group has 6 animals and induced the hepatic failure. Silymarin was used as reference standard. Aqueous extract of flowers of C. indicum treated in a different dose which was compared with control group of animals. Results: Aqueous extract of flowers of C. indicum reduced the level of aspartate transaminase (AST), alanine transaminase (ALT), serum bilirubin, protein, triglycerides, and cholesterol compared than paracetamol treated Group II animals. Histopathological studies were confirmed that reduction of necrosis and inflammation in the liver cells. Conclusion: Thus, these results revealed that the aqueous extract of flowers of C. indicum shown very significant (p<0.01) hepatoprotection against paracetamol-induced hepatic failure in animal model by reducing AST, ALT, serum total bilirubin, protein, triglycerides, and cholesterol levels.