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首页> 外文期刊>Asian Journal of Pharmaceutical and Clinical Research >HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACTS OF CHRYSANTHEMUM INDICUM FLOWERS ON PARACETAMOL INDUCED LIVER INJURY IN ALBINO RATS
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HEPATOPROTECTIVE ACTIVITY OF AQUEOUS EXTRACTS OF CHRYSANTHEMUM INDICUM FLOWERS ON PARACETAMOL INDUCED LIVER INJURY IN ALBINO RATS

机译:菊花花提取物对白藜芦醇致大鼠肝损伤的肝保护作用。

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摘要

Objective: The present investigation was evaluated that protective activity of aqueous extract of flowers of Chrysanthemum indicum studied against paracetamol-induced hepatotoxicity in animal model. Methods: Bioactive functional groups, such as alcohol, carboxylic acid, and amines, were present in the aqueous extract of flowers of C. indicum identified by Fourier transform infrared spectroscopy. The animals were grouped into 5 and each group has 6 animals and induced the hepatic failure. Silymarin was used as reference standard. Aqueous extract of flowers of C. indicum treated in a different dose which was compared with control group of animals. Results: Aqueous extract of flowers of C. indicum reduced the level of aspartate transaminase (AST), alanine transaminase (ALT), serum bilirubin, protein, triglycerides, and cholesterol compared than paracetamol treated Group II animals. Histopathological studies were confirmed that reduction of necrosis and inflammation in the liver cells. Conclusion: Thus, these results revealed that the aqueous extract of flowers of C. indicum shown very significant (p<0.01) hepatoprotection against paracetamol-induced hepatic failure in animal model by reducing AST, ALT, serum total bilirubin, protein, triglycerides, and cholesterol levels.
机译:目的:本研究旨在评价印度菊花水提取物对扑热息痛引起的动物模型肝毒性的保护作用。方法:通过傅里叶变换红外光谱法鉴定的印度隐花的水提取物中存在生物活性官能团,例如醇,羧酸和胺。将动物分为5只,每组有6只动物,并引起肝衰竭。水飞蓟素用作参考标准。用不同剂量处理的印度蜡梅花的水提取物,将其与动物对照组进行比较。结果:与对乙酰氨基酚治疗的II组动物相比,印度贯叶菊花的水提取物降低了天冬氨酸转氨酶(AST),丙氨酸转氨酶(ALT),血清胆红素,蛋白质,甘油三酸酯和胆固醇的水平。组织病理学研究证实肝细胞坏死和炎症减少。结论:因此,这些结果表明,通过降低AST,ALT,血清总胆红素,蛋白质,甘油三酸酯和甘油三酯,印度蜡梅花的水提物显示出非常显着的(p <0.01)肝保护作用,以防止对乙酰氨基酚引起的肝衰竭。胆固醇水平。

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