ANTIOXIDANT AND ANTICANCER ACTIVITIES OF HEXANE FRACTION FROM CARICA PAPAYA L. MALE FLOWER

摘要

Objective: This study examined the antioxidant and anticancer potential activities of the hexane fraction from the male flower of Carica papaya L., which is long been known to be a very important source of nutraceutical and pharmaceutical. Methods: Standard fractioned (fraction) method with phytochemical screening. The antioxidant activity was carried out using the α,α-diphenyl-β- picrylhydrazyl method and the anticancer potential activity was carried out using 3-(4,5-dimethythiazol-. 2-yl)-2,5-diphenyl tetrazolium bromide assay to check the cytotoxic activity on WiDr (colon cancer cell) and Vero cell (normal cell). Result: Phytochemical screening of the hexane fraction from the male flower of papaya shows a strong sign of triterpenoids and steroids; while the IC50 of antioxidant value was 100.81±1.180 μg/ml. Cytotoxic effect shows that the hexane fraction of papaya male flower had selectivity to WiDr cell (colon cancer cell). Conclusion: This study provides evidence that C. papaya L. male flower possesses antioxidant activity, as well as cytotoxic and chemopreventive properties. It might be beneficial as medicinal plant as an antioxidant and anticancer nutraceutical and pharmaceutical sources.