Effect of Dialysis on Plasma Lipid Peroxidation and Lipid Profile in Haemodialysis Patients

摘要

This research has been set up to study the possibility of lipid peroxidation and lipid profile variation in haemodialysis patients. Twenty two patients with Chronic Renal Failure (CRF) disease who werehaemodialyzed at 5th Azar hospital of Gorgan Dialysis Center were recruited for this study (2005). The patients don?t have coronary heart disease . 22 age and sex matched healthy control were recruited for this study. Plasma levels of lipid peroxidation and lipid profile were determined in haemodialysis patients and compare with control groups. The results from this research projects indicate that Plasma levels of lipid peroxidation (1.27±0.23 nmol mL^-1) and triglyceride (195.22±20.28 mg dL^-1) in haemodialysis patients were significantly increased when compared with control subjects (0.98±0.17 nmol mL^-1, 151.09±5.74 mg dL^-1, respectively), whereas plasma level of total cholesterol (171.68±16.30 mg dL^-1), High Density Lipoprotein cholesterol (HDL-C, 44.13±5.38 mg dL^-1) in haemodialyzed patients showed no significant difference when compared with control subjects (170.77±14.73 and 44.77±5.29 mg dL^-1, respectively). The changes in level of plasma lipid peroxidation and triglyceride in haemodialyzed patients, maybe related with the patient uremia, dialysis membrane and the dialysis process. The metabolic alterations accompanying renal failure may be responsible for dyslipidemia independent of the fat distribution in haemodialysis patients. These states of affairs may play an important role in progress of cardiovascular abnormality in haemodialyzed patients. Due to this conditions a review of haemodialysis membrane, the techniques used in the dialysis, the consumption of various oral antioxidant, the elimination of active oxygen from the dialysis surrounding are among the measures which can prevent sudden cardiovascular abnormality in the haemodialysis patients.