The analysis mutation of the CARD 15 gene variants in chronic periodontitis

摘要

Purpose of this study was to determine the variant of CARD 15 gene mutations with periodontitis chronic. Identified by using polymerase chain reaction (PCR) and folowed by using restriction fragment length polymorphism analysis (RFLP). CARD 15 gene mutation with chronic periodontitis were found heterozygote mutation and homozygote mutation variants base on statistical analysis there were significant with control group (p= 0,005) and also was founded genetics variation that changed the composition of C → T nucleotide at codon 802 in exon 4 amino acid, from alanine to valine.