Optimization for ultra high pressure extraction of Scutellaria barbata by central composite design-response surface methodology

摘要

A high performance?ultra high pressure (UHP) technique was developed for high yield extraction of bioactive components from?Scutellaria barbata?at lower temperatures, within a short time, and for less power consumption. The UHP process of scutellarin, luteolin and apigenin?from?S. barbata?was optimized by using central composite design-response surface methodology (CCD-RSM).?The optimum result of UHP?was compared with?those of?the?conventional?extractionmethods of circulation reflux, ultrasonic and microwave. The optimal conditions for extraction?were: extracting pressure of 204.72 MPa, ethanol concentration of 61.44% and solid-liquid ratio of 1:78.79. The extraction?yield?of scutellarin, luteolin and apigenin?from?S. barbata?were: 12.38, 1.76 and 0.23 mg g-1, respectively and an integrated score of 7.18. This showed that the UHP was more effective than the conventional extraction methods.