Sequence and Phylogenetic Analysis of Bovine Rotavirus Isolates (G6 Genotypes) from India

摘要

Rotaviruses (RVs) are among the most important enteric pathogens responsible for significant morbidity and mortality in bovine calves throughout the world. We describe here the sequence characterization of bovine group A rotavirus isolate BR108 obtained from Northern India (semi-arid zone) and P-43 isolate isolated from foot-hills of western Himalayan region (Uttarakhand). The isolates were characterized by phylogenetic analysis of one of its major outer capsid protein gene, VP7. Analysis of VP7 gene sequences of both the isolates (BR-108 and P-43) revealed higher sequence homology of 95.6% at nucleotide and 98.3% at amino acid level with bovine rotavirus G6 genotype from Punjab. The findings are suggestive of inter-geographical boundaries of states transmission of bovine rotaviruses which along with diverse genotypes put a heavy burden on bovine population