Serum levels of the S100B protein and neuron-specific enolase are associated with mortality in critically ill patients

摘要

Introduction. Evaluation of the prognostic potential ofthe S100B protein and neuron-specific enolase (NSE)as predictors of mortality in critically ill patients in intensivecare units (ICU). Materials and Methods. Thestudy was conducted on 62 patients. Basic clinical variablesand blood samples for S100B and NSE level testingwere obtained during the first four days after admission.Mortality was described as the patient’s death duringhospitalization in the ICU. Results. 35% of the patientshad died. The level of S100B and NSE was significantlyhigher in non-survivors in comparison with survivors(p=0.007 and p=0.02, respectively). Mortality risk wassignificantly higher in patients with higher levels of biomarkersthan the reference values for S100B (OR 9.00;95% CI 2.38–33.99; p<0.001) as well as for NSE (OR 5.75;95%CI 1.31–25.27; p=0.016). Receiver operating characteristicproved that S100B is a better mortality predictorthan NSE (AUC 0.76 for S100B and 0.68 for NSE). Fromall the other variables, the Apache II score turned out tobe the only significant predictor of mortality (AUC 0.88).Conclusion. There is a significant correlation betweenmortality in the ICU and increased serum concentrationof S100B and NSE. This correlation is stronger for S100B.Testing for serum levels of S100B and NSE may be usefulfor prediction of treatment outcomes in the ICU patients.