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首页> 外文期刊>Acta Innovations >INFLUENCE OF FISH COLLAGEN ON VISCOELASTIC PROPERTIES AND SOL-GEL PHASE TRANSITION OF CHITOSAN SOLUTIONS
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INFLUENCE OF FISH COLLAGEN ON VISCOELASTIC PROPERTIES AND SOL-GEL PHASE TRANSITION OF CHITOSAN SOLUTIONS

机译:鱼胶原蛋白对壳聚糖溶液的粘弹性和溶胶凝胶相变的影响

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The thermosensitive hydrogels are widely used in tissue engineering due to their non-invasive application. Special interest of researchers, due to the specific characteristics of both materials, is aimed at composites of natural origin obtained from chitosan hydrogels combined with collagen. The mechanical properties of the thermosensitive chitosan-fish collagen hydrogels and the sol-gel phase transition parameters were determined by the rotational rheometry measurement techniques. Based on comparison of the obtained storage modulus G' curves, it was found that the addition of collagen negatively affects the mechanical properties of composite scaffolds. The addition of this protein substance decreases their elasticity. Only the smallest concentration (0.25g collagen/1 g chitosan) of collagen improves the mechanical properties of composite hydrogels, from 56 kPa to 61 kPa. Conducted non-isothermal studies allowed to conclude that the addition of collagen causes an increasing temperature of sol-gel phase transition. However, the observed changes are not a monotone function of the biopolymer concentration.
机译:由于它们的非侵入性应用,热敏水凝胶被广泛用于组织工程。由于两种材料的特定特性,研究人员特别感兴趣的是针对从壳聚糖水凝胶与胶原蛋白结合而成的天然复合材料。通过旋转流变仪测量技术确定了热敏壳聚糖-鱼胶原蛋白水凝胶的机械性能和溶胶-凝胶相变参数。基于所获得的储能模量G'曲线的比较,发现胶原的添加对复合支架的机械性能产生负面影响。这种蛋白质物质的添加降低了它们的弹性。只有最小浓度的胶原蛋白(0.25 g胶原蛋白/ 1 g壳聚糖)才能从56 kPa到61 kPa改善复合水凝胶的机械性能。进行的非等温研究可以得出结论,胶原蛋白的添加会导致溶胶-凝胶相变温度升高。但是,观察到的变化不是生物聚合物浓度的单调函数。

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