Coagulation Activity in Elderly Patients With Hip Fracture Measured by Prothrombin Fragment 1 + 2 in Urine

摘要

Objective: The purpose of this study was to document the uF1 + 2 excretion in elderly patients during and after a hip fracture (HF). Methods: The study was a prospective pilot study. Spot urine samples were collected immediately after admission and every morning until surgery. After surgery, urine samples were collected on days 1, 5, 7, 14, and at follow-up on day 90 (±10). Results: A total of 24 women and 7 men with HF completed the study. The median uF1 + 2 level was significantly increased on the day of admission relative to the median level at follow-up. Maximum levels were seen on day 1 with a decreasing tendency until follow-up. Patients treated with a hemiarthroplasty had higher median uF1 + 2 levels on all days compared with patients treated with osteosynthesis. Conclusion: A substantial coagulation activity, indicated by high median levels of uF1 + 2, was seen at admission and during the first week after HF.