An Evaluation of the Modified Diagnostic Criteria for DIC Established by the Japanese Society of Thrombosis and Hemostasis

摘要

Objective: We evaluated the modified diagnostic criteria for disseminated intravascular coagulation (DIC), which was publishedby the Japanese Society of Thrombosis and Hemostasis (JSTH) in 108 patients with suspected infectious DIC. Material andmethods: The diagnoses of the patients were as follows: DIC (n ? 63), pre-DIC (n ? 22), and non-DIC (n ? 45). The efficacy ofthe diagnostic criteria for DIC was evaluated using a receiver–operating characteristic analysis. Results: Although the area underthe curve for global coagulation test (GCT) scores in the diagnosis of ‘‘DIC’’ was high that for the diagnosis of ‘‘DIC and pre-DIC’’was low, suggesting that the addition of antithrombin (AT), soluble fibrin (SF)/thrombin–AT complex (TAT), and reduced plateletcount (PLT) values was required to diagnose ‘‘DIC and pre-DIC.’’ Using GCT score with the AT, SF/TAT, and reduced PLT values,the cutoff value of the DIC score for the diagnosis of ‘‘DIC and pre-DIC’’ was 5 points. Discussion and conclusion: Themodified JSTH’s diagnostic criteria for DIC, which used the GCT score and the reduced PLT, AT, and TAT/SF values, were usefulfor diagnosing "DIC and pre-DIC.".