Microparticles and Kawasaki disease: a marker of vascular damage?

摘要

BACKGROUND: Microparticles (MPs) are increased in diseases characterised by endothelial injury. Kawasaki disease (KD) damages the endothelium provoking life-threatening involvement of coronary arteries. OBJECTIVES: To compare KD MPs vs. controls. METHODS. Thirty KD and 20 controls were enrolled. MPs were stained with monoclonal antibodies against platelets, endothelial cells (EC), monocytes, T and B cells, neutrophils, and quantified by FACS. RESULTS: The total number of MPs was significantly increased in KD versus controls (193x105?±0.6x105 vs. 94x105?±0.9x105 million/ml plasma p=0.01) and vs. KD after IVIG therapy (132x105?±0.4x105million/ml plasma p=0.01). EC and T cells were the major source of MPs in KD (72x105?±1x105 vs. 3x105?±0.9x105million/ml plasma for T cells p=0.005; 76x105?±0.7x105 vs. 45x105?±0.4x105 million/ml plasma for EC p