Small Cell Carcinoma of Oesophagus: A Rare Case Report and Literature Review

摘要

Background: Primary small cell oesophageal carcinoma (SCOC) is a rare, highly aggressive tumor with high incidence of metastasis and associated with poor outcome. Case report: A 55 year old Malay lady presented to HUSM with progressive dysphagia associated with symptomatic anemia. Clinically, patient was pale and there was mass palpable at epigastric region. Biopsy revealed findings of tumor cells arranged in solid sheets exhibiting mild nuclear pleomorphism having round and hyperchromatic nuclei, inconspicuous nucleoli with frequent mitotic figures. Histopathological examination confirmed the diagnosis of SCOC. She was planned to start on CDDP/ETO for 3-4 cycles and planned for repeat CT after chemotherapy to assess the response. Unfortunately, she was only able to complete her first cycle chemotherapy partially as she had persistent low haemoglobin secondary to ongoing bleeding from tumor. Conclusions: The optimal treatment for SCOC is unclear. It is wise to consider radical surgery to LD patients who is fit.