Acute basophilic leukemia associated with the t(16;21)(p11;q22)/ FUS - ERG fusion gene

摘要

Key Clinical Message We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS - ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil-associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/ FUS - ERG and basophilic differentiation remains unclear.