Assessment of Ciliary Beat Pattern: Variability in Healthy Control Subjects Has Implications for Use as Test for Primary Ciliary Dyskinesia

摘要

FOR RELATED ARTICLE SEE PAGE 993Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder of ciliary biogenesis, structure, and function. Diagnosis can be challenging. Several diagnostic tests have been used, including assessment of ciliary beat pattern by high-speed videomicroscopy, ciliary ultrastructure by transmission electron microscopy, nasal?nitric oxide measurement, and, more recently, immunofluorescence testing using a panel of antibodies and genetic testing using a panel of PCD-associated genes. All of these tests require specialized equipment and expertise for interpretation and none of these tests has the accuracy needed for a “stand?alone” diagnostic test.Consensus statements focused on diagnosis and management of PCD have been published by the European Respiratory Society (ERS) task force in 2009