The Comparative Evaluation of the Time to Peak Concentration and the Terminal Half-Life of Two Products Based on Praziquantel in a Bioequivalence Study

摘要

Tmax represents the amount of time necessary to achieve the maximum concentration of the drug in the systemic circulation. The half time of a drug represents the mandatory time required to reduce the drugs concentration from the plasma to half, after reaching a steady state.Evaluating and comparing the time to attain the maximum drug concentration in the blood (Tmax) and to assess the half-time (T1/2) of praziquantel in two drug formulations, in a bioequivalence study. These measurements were carried out with regard to the peak concentration (Cmax) of the drugs. In the study, were included 12 healthy cats, of European breed. According to the study protocol, the cats received praziquantel, in a dosage of 20 mg, in two phases, at different time periods, for three consecutive days. A series of parameters were determined, including Tmax, T1/2, and Cmax. It was observed that, at the same amount of praziquantel (20 mg), the results were different. For the first group, the maximum substance concentration was at 1.18 ± 0.4 hours and for the second group, was at 1.27 ± 0.26 hours. The half-time was at 1.07 ± 0.22 hours for the first group while for the second group was at 1.84 ± 1.16 hours. The results of the investigated parameters revealed mainly individual differences, which were situated within the bioequivalence standards.