Triweekly administration of parathyroid hormone (1–34) accelerates bone healing in a rat refractory fracture model

摘要

Some reports have shown that intermittent parathyroid hormone (PTH) (1–34) treatment for patients with delayed union or nonunion have led to successful healing. In this study, we investigated whether systemic intermittent administration of PTH (1–34) has a beneficial effect on bone healing in a rat refractory fracture model. We created a refractory femoral fracture model in 32 rats with periosteal cauterization that leads to atrophic nonunion at 8?weeks after surgery. Half the rats received subcutaneous intermittent human PTH (1–34) injections at a dosage of 100?μg/kg, thrice a week for 8?weeks. The other half received the vehicle only. At 8?weeks after fracture, radiographic, histological and mechanical assessments were performed. Radiographic assessments showed that the union rate was significantly higher in the PTH group than in the control group (P?