SUBLINGUAL DELIVERY OF HUMAN PARATHYROID HORMONE 1-34 (PTH)USING A DELIVERY AGENT (DA) IN A DOG MODEL

机译：狗模型中人副甲状腺激素1-34（PTH）的舌下递送

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The feasibility of sublingual delivery of PTH wasdemonstrated using an EMISPHERE? delivery agent(DA) in a dog model. Preliminary data showed thata sublingual tablet formulation of PTH/DA wascomparable to a sublingual solution formulation and6-fold more effective than the solution dosed orally(PO). The bioavailability of PTH relative tosubcutaneous injection (SC) was approximately16%.

机译：PTH的舌下传递的可行性是使用EMISPHERE进行演示？送货员（DA）在狗模型中。初步数据显示 PTH / DA的舌下片剂制剂为可与舌下解决方案相提并论; 比口服溶液有效六倍（PO）。相对于PTH的生物利用度皮下注射（SC）大约为 16％。

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《Annual meeting exposition of the Controlled Release Society》|2005年|1-2|共2页
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Jongbin Lee; Nai Fang Wang; Ehud Arbit; Steven Dinh; Puchun Liu;
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中图分类药学;
关键词
sublingual delivery; PTH absorption;

机译：舌下传递; PTH吸收;
入库时间 2022-08-26 14:53:51

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专利

1. Effect of irradiation on parathyroid hormone PTH(1-34) coated on a novel transdermal microprojection delivery system to produce a sterile product--adhesive compatibility. [J] . Ameri M, Wang X, Maa YF Journal of pharmaceutical sciences. . 2010,第4期

机译：辐照对甲状旁腺激素PTH（1-34）的影响，该甲状旁腺激素涂覆在新型透皮微突递送系统上以产生无菌产品-粘合剂相容性。
2. Parathyroid Hormone PTH(1-34) Formulation that Enables Uniform Coating on a Novel Transdermal Microprojection Delivery System [J] . Mahmoud Ameri, Shelley C. Fan, Yuh-Fun Maa Pharmaceutical Research . 2010,第2期

机译：甲状旁腺激素PTH（1-34）配方，可在新型透皮微突输送系统上实现均匀涂层
3. Parathyroid hormone PTH(1-34) formulation that enables uniform coating on a novel transdermal microprojection delivery system. [J] . Ameri M, Fan SC, Maa YF Pharmaceutical research . 2010,第2期

机译：甲状旁腺激素PTH（1-34）制剂，可在新型透皮微喷射递送系统上均匀包衣。
4. SUBLINGUAL DELIVERY OF HUMAN PARATHYROID HORMONE 1-34 (PTH)USING A DELIVERY AGENT (DA) IN A DOG MODEL [C] . Jongbin Lee, Nai Fang Wang, Ehud Arbit, Annual meeting exposition of the Controlled Release Society . 2005

机译：狗模型中人副甲状腺激素1-34（PTH）的舌下递送
5. The effect of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHRP) on sodium ion/proton exchanger activity and analysis of signal transduction mechanisms. [D] . Azarani, Arezou. 1996

机译：甲状旁腺激素（PTH）和甲状旁腺激素相关肽（PTHRP）对钠离子/质子交换剂活性的影响以及信号转导机制的分析。
6. The Calcemic Response to Continuous Parathyroid Hormone (PTH)(1-34) Infusion in End-Stage Kidney Disease Varies According to Bone Turnover: A Potential Role for PTH(7-84) [O] . Katherine Wesseling-Perry, G. Chris Harkins, He-jing Wang, -1

机译：终末期肾脏疾病对连续甲状旁腺激素（PTH）（1-34）输注的钙血症反应因骨转换而异：PTH（7-84）的潜在作用
7. Parathyroid Hormone (PTH)-(1-34), Nle8,18,Tyr34PTH-(3-34) Amide, PTH-(1-31) Amide, and PTH-Related Peptide-(1-34) Stimulate Phosphatidylcholine Hydrolysis in UMR-106 Osteoblastic Cells: Comparison with Effects of Phorbol 12,13-Dibutyrate [O] . A. T. K. Singh 1999

机译：甲状旁腺激素（PTH） - （1-34），nle8,18，tyr34 pth-（3-34）酰胺，pth-（1-31）酰胺和pth相关肽 - （1-34）刺激磷脂酰胆碱UMR-106骨细胞水解中的水解：与Phorbol 12,13-二丁酸的影响的比较

SUBLINGUAL DELIVERY OF HUMAN PARATHYROID HORMONE 1-34 (PTH)USING A DELIVERY AGENT (DA) IN A DOG MODEL

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