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首页> 外文期刊>BMC Pulmonary Medicine >Occupational risk factors for idiopathic pulmonary fibrosis in Southern Europe: a case-control study
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Occupational risk factors for idiopathic pulmonary fibrosis in Southern Europe: a case-control study

机译:南欧特发性肺纤维化的职业危险因素:病例对照研究

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Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive fibrosing interstitial pneumonia of unknown cause associated with the histopathologic and/or radiologic pattern of usual interstitial pneumonia (UIP). Occupational risk factors have been proposed to be associated with UIP. The aim of this case-control study is to evaluate the relationship between UIP pattern and occupational exposure in Southern Europe. Sixty nine cases with a UIP radiological pattern at CT-scan were selected from a clinical database of the University Hospital of Perugia, Umbria, between January 2010 and December 2013. Controls (n?=?277) not reporting doctor diagnosed pulmonary fibrosis, were ascertained casually among general population from the same catching area of cases. Data were collected by a questionnaire used previously in a similar study. Logistic regression models, adjusted for gender, age and smoking, were performed to evaluate the association between UIP and occupational exposure. Farmers, veterinarians and gardeners (OR?=?2.73, 95%CI?=?1.47–5.10), metallurgical and steel industry workers (OR?=?4.80, 95%CI?=?1.50–15.33) were occupations associated with UIP. Metal dust and fumes and organic dust were risk factors for UIP. Increasing the length of occupational exposure in jobs at risk of pulmonary fibrosis, increased the risk of having UIP. This case control study confirm partially the results from previous similar studies. Some discrepancies could be explained by the different geographical origins of the population under study, reflecting also different occupational exposures.
机译:特发性肺纤维化(IPF)是一种原因不明的慢性进行性纤维化间质性肺炎,与通常的间质性肺炎(UIP)的组织病理学和/或放射学特征有关。已经提出职业危险因素与UIP有关。本病例对照研究的目的是评估南欧的UIP模式与职业暴露之间的关系。在2010年1月至2013年12月之间,从翁布里亚佩鲁贾大学医院的临床数据库中选择了69例CT扫描具有UIP放射学特征的病例。未报告医生诊断为肺纤维化的对照组(n = 277)为从同一病例的同一地区,在普通人群中随意确定。通过以前在类似研究中使用的调查表收集数据。进行了针对性别,年龄和吸烟进行调整的逻辑回归模型,以评估UIP和职业暴露之间的关联。与UIP相关的职业是农民,兽医和园丁(OR?=?2.73,95%CI?=?1.47-5.10),冶金和钢铁行业工人(OR?=?4.80,95%CI?=?1.50-15.33)。 。金属粉尘,烟雾和有机粉尘是UIP的危险因素。在有肺纤维化风险的工作中职业接触的时间增加,增加了患UIP的风险。该病例对照研究部分证实了先前类似研究的结果。某些差异可以由所研究人口的不同地理起源来解释,也反映了不同的职业暴露。

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