Investigation of potential traces of pluripotency in germinal-center-derived B-cell lymphomas driven by MYC

摘要

Human pluripotent stem cells (hPSCs) are defined by their indefinite self-renewal in vitro and their potential to differentiate into cells representative of all lineages of the mammalian gastrulation embryo. 1 Several similarities link these genomically normal cells with features salient to malignancies, 2 for example, when injected into immunodeficient mice, hPSCs give rise to tumors closely resembling teratomas. 1 hPSCs can be induced from somatic cells by the transient overexpression of four genes ( POU5F1, KLF4, SOX2 and MYC ). The induction of pluripotency in somatic cells shares again several molecular mechanisms with malignant transformation.