目的：探讨伴有生发中心增生的血管免疫母细胞性 T 细胞淋巴瘤的临床、病理形态学及免疫表型特点。方法对4例伴有生发中心增生的血管免疫母细胞性 T 细胞淋巴瘤标本进行形态学、免疫组化及 EB 病毒原位杂交观察，并进行临床随访。结果4例病例均显示生发中心增生伴血管免疫母细胞性增生，但是套区变薄，境界不清。3例表达 CD10，2例表达 CXCL13，4例表达 PD -1。4例均见 EBV（+）的母细胞。4例在就诊时均处于临床进展期，3例得到随访，其中2例死亡。结论诊断伴有生发中心增生的血管免疫母细胞性 T 细胞淋巴瘤，必须将形态学、免疫表型特征和临床表现密切结合。%Objective To explore the clinicopathological features of angioimmunoblastic T - cell lymphoma with hyperplastic germinal centers. Methods Four cases of angioimmunoblastic T - cell lymphoma with hyperplastic germinal centers were studied by light microscopy,im-munohistochemical method and in situ hybridization. Follow - up had been taken for 6 ~ 31 months in 3 cases. Results Follicular hyperplasia a-long with angioimmunoblastic proliferation had been seen in 4 cases,as well as poorly developed mantle zones with ill - defined borders. The ex-pression of CD10 had been seen in 3 cases,and positive expression of CXCL13 was seen in 2 cases,and expression of PD - 1 in 4 cases. EBV ( + )immunoblasts were present in 4 cases. Their clinical courses were characterized by relentless and rapid progress,and 2 patients died within 31 months. Conclusion The accurate diagnosis of angioimmunoblastic T - cell lymphoma with hyperplastic germinal centers. needs combination of histopathological examination,immunophenotype detection and study of clinical features.
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