Monte Carlo (MC) simulation is widely recognized as a gold standard in biophotonics for its high accuracy. Here we analyze several issues associated with tetrahedron-based optical Monte Carlo simulation in the context of TIM-OS, MMCM, MCML, and CUDAMCML in terms of accuracy and efficiency. Our results show that TIM-OS has significant better performance in the complex geometry cases and has comparable performance with CUDAMCML in the multi-layered tissue model.
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