Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome

Sayuri Shirai; Takashi Yasuda; Hiroki Tsuchida; Shingo Kuboshima; Yusuke Konno; Yoshinori Shima; Takeo Sato; Shigeo Hatta; Keisou Masuhara; Kenjirou Kimura

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Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome

机译：餐前微乳环孢素治疗对难治性肾病综合征患者有效

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摘要

The present study evaluated the clinical efficacy and pharmacokinetics of microemulsion cyclosporine A (ME-CyA) with modification from postprandial to preprandial administration in adult patients with refractory nephrotic syndrome.

机译：本研究评估了成人难治性肾病综合征患者从餐后到餐前服用微乳环孢素A（ME-CyA）的临床疗效和药代动力学。

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来源
《Clinical and Experimental Nephrology》 |2009年第2期|123-129|共7页
作者
Sayuri Shirai; Takashi Yasuda; Hiroki Tsuchida; Shingo Kuboshima; Yusuke Konno; Yoshinori Shima; Takeo Sato; Shigeo Hatta; Keisou Masuhara; Kenjirou Kimura;
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作者单位

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

Department of Pharmacy St. Marianna University School of Medicine Kawasaki Japan;

Department of Pharmacy St. Marianna University School of Medicine Kawasaki Japan;

Division of Nephrology and Hypertension Department of Internal Medicine St. Marianna University School of Medicine 2-16-1 Sugao Miyamae-ku Kawasaki Kanagawa 216-8511 Japan;

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正文语种 eng
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关键词
Microemulsion cyclosporine; Preprandial administration; Refractory nephrotic syndrome;

机译：微乳环孢菌素;静脉给药;难治性肾病综合征;

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专利

1. Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome [J] . Sayuri Shirai, Takashi Yasuda, Hiroki Tsuchida, Clinical and experimental nephrology . 2009,第5期

机译：餐前微乳环孢素治疗对难治性肾病综合征患者有效
2. Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome [J] . Sayuri Shirai, Takashi Yasuda, Hiroki Tsuchida Clinical and experimental nephrology . 2009,第2期

机译：餐前微乳环孢素治疗对难治性肾病综合征患者有效
3. Benefits of cyclosporine absorption profiling in nephrotic syndrome: preprandial once-daily administration of cyclosporine microemulsion improves slow absorption and can standardize the absorption profile. [J] . Takeda A, Horike K, Onoda H, Nephrology. . 2007,第2期

机译：肾病综合征中环孢素吸收曲线的好处：餐前每天一次给予环孢素微乳可以改善缓慢吸收并可以使吸收曲线标准化。
4. New Insight into Idiopathic Nephrotic Syndrome: Strategy Based on Urinary Exosomes [C] . Elisa Barigazzi, Lucia Santorelli, W. Morello, NATO Advanced Study Institute on Detection, Diagnosis and Health Concerns of Toxic Chemical and Biological Agents . 2020

机译：对特发性肾病综合征的新洞察：基于泌尿前的策略
5. Evaluation of the pharmacokinetic-pharmacodynamic relationship for the matrix metalloproteinase inhibitory effect of COL-3 following oral administration to patients with refractory metastatic cancer. [D] . Rudek, Michelle Ann. 2001

机译：口服给予难治性转移癌患者后，COL-3对基质金属蛋白酶抑制作用的药代动力学与药效关系的评价。
6. Cyclosporine A for the treatment of refractory nephrotic syndrome with renal dysfunction [O] . XIANG GAO, YIYI MA, LIJUN SUN, -1

机译：环孢霉素A治疗难治性肾病综合征肾功能不全
7. Optimal Dosing Regimens of Cyclosporine in Patients with Refractory Nephrotic Syndrome [O] . Masayo Ueno, Atsushi Yamauchi, Satoru Ogahara, 2007

机译：难治性肾病综合征患者环孢菌素的最佳剂量

Preprandial microemulsion cyclosporine administration is effective for patients with refractory nephrotic syndrome

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