Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser/Thr protein kinase

摘要

A novel full-length cDNA encoding a putative serine/threonine kinase has been isolat- ed from a human testis cDNA library. A nucleotide sequence of 1225 bp length has been deter- mined containing an open reading frame of 1044 nucleotides (encoding 348 amino acids). In view of its degree of homology to members of the Ser/Thr protein kinase family and the closest relationship to Mus musculus STK-1, the predicted product was designated by the name of HUMSTK-1. Its mRNA is present in large amounts in thymus, and small amounts in testis, Small intestine and colon.