Hyperoxia-induced ling injury in premature rat; description of a suitable model for the study of lung diseases in newborns

摘要

Conclusions The premature rat model is rela- tively cheap, readily available and has a high survival rate. Pulmonary surfactant and AOE systems are im- mature. These properties make them a suitable model for the study of acute and chronic lung damage related to prematurity and O_2 toxicity. Objective To provide suitable animal model (hyperoxia-induced premature rat lung damage)for re- search of bronchopulmonary dysplasia (BPD) and to better understand pathogenesis of BPD and look for ef- fective drugs to prevent and treat BPD.