The present invention provides inducible transgenic mouse models of lung cancer and lung remodeling diseases. In one embodiment, the present invention provides pre-clinical mouse models in which lung cancer and a lung disease of interest can be induced "at will" at any time points by the presence and withdrawal of doxycycline. The transgenic mouse model of the present invention recapitulates molecular, cellular and pathological characteristics of human lung cancer and lung remodeling diseases including emphysema, COPD, and pulmonary fibrosis.
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