Genetic heterogeneity foe familial hypertrophic cardiomyopathy in Chinese: analysis of six Chinese kindreds

摘要

Conclusions These results provide further vie- dence that FHCM in Chinese is genetically heteroge- neous. Chromosome 14q1 locus, probably the β myosin heavy chin gene, is important as the molecu- lar basis for FHCM in Chinese. Objective Familial hypertrophic cardiomyopaty (FHCM) is a primary myocardial disease characterized by unexplained ventricular hypertropy. The application of the techniques of reverse genetics has identified at least five chromosomal loci as the major causes for FHCM in diverse ethnic populations, suggesting sub- stantial genetic heterogeneity for FHCM.