Serum immunoreactive bone sialoprotein children, healthy adults, and patients with renal hepatic failure: physiological and pathological veriability

摘要

Serum immunoreactive bone sialoprotein(BSP)is a non- collageneous protein of bone although it is mainly synthesized by osteoblasts, it is believed that its quantification represents processes preferentially linked to bone resorption. This effect may be due to the protein's role in cell-matrix Adhesion processes in attachment of osteoclasts to bone. To Determine the physiological and pathological variability, serum Levels of BSP(by RIA)were studied in:①54 healthy children Aged 0-20 years(M/F: 30/24);②healthy males(n = 74); ③healthy pre-(n=91)and postmenopausal(n=7)females; ④patients with renal(RF; n = 20)and hepatic(HF; n = 20) failure.