Study on Effect of Compound Sal via Pellet in Preventing Atrial Fibrillation with Left Atrial Thrombosis

摘要

Atrial fibrillation (AF) is a kind of common arrhythmia, which, besides affecting cardiac function, has another serious outcome, that is, it is easy to form atrial thrombosis and induce thrombus/embolus, especially cerebral embolus. The incidence of left atrial thrombosis (LAT) could reach 25%-30%, the incidence of embolic complication per year could reach 2.98%-6.30%, even 20% or more<2'3). To prevent thrombosis so as to lower the incidence of cerebral stroke and other embolic complications has been so far the focal point of AF treatment. The present study is to observe the effect of compound Salvia pellet (CSP) in treating AF patients with anti-coagulatory treatment indication on concentration change of plasma thromboxane B_2 (TXB_2), 6-keto-postglandin F_(1α) (6-keto-PGF_(1α)) and LAT, embolus incidence, to explore the efficacy and feasibility of Salvia miltiorrhiza in preventing LAT of AF patients.